The diagram depicts how excessive IL-13production, often triggered by antigenic epitopes, can lead to a cascadeof adverse effects including mucus production, lung inflammation,cytokine storm, tissue fibrosis, and airway hyperresponsiveness, ultimatelycontributing to conditions like severe allergic reactions and complicationsin viral infections such as COVID-19.5 Thisfigure highlights the clinical relevance and therapeutic importanceof targeting IL-13 and accurately predicting IL-13-inducing epitopes. This evidence concerns the gene IL13 and airway hyperresponsiveness.