Additionally, parthenolide increases IL-10 expression by improving the balance of Treg/Th17 in intestinal mucosa, which is mediated by increased production of microbiota-derived SCFAs [21]; moreover, by increasing the content of SCFAs, Pulsatilla decoction repairs the colonic mucosal barrier in ulcerative colitis mice by increasing IL-10 concentration [22]. This evidence concerns the gene IL10 and ulcerative colitis.