JAK1 and colorectal carcinoma: Upon binding to glycoprotein 130 (gp130), IL-6 primarily regulates CRC development through three signaling pathways: Src Homology 2 Domain-containing Phosphatase 2 - Rat Sarcoma - Extracellular Signal-Regulated Kinase (Shp2-Ras-ERK), Janus Kinase 1/2 (JAK1/2)-STAT3, and Phosphoinositide 3-Kinase - Protein Kinase B - Mechanistic Target of Rapamycin (PI3K-Akt-mTOR)56.