The study also found that overexpression of FOXM1 increases the expression of Ki-67, PCNA, and MMP-2/-9, which reverses the inhibition of TSN IIA-induced proliferation and migration of GC cells, demonstrating the inhibition of GC cell proliferation and migration by downregulation of FOXM1 by TSN IIA. This evidence concerns the gene MMP2 and gastric cancer.