AKT1 and gastric cancer: Ding et al. conducted data mining and statistical analysis of the mechanism of Sijunzi Decoction in the treatment of GC based on network pharmacology, and the study showed that Sijunzi Decoction inhibits angiogenesis by downregulating the expression of VEGFA, iNOS, and COX-2, and induces cell apoptosis by upregulating the ratio of Bax/Bcl2 to regulate the PI3K/AKT pathway, so the further development of GC is inhibited102.