Studies have shown that oxymatrine can effectively inhibit the phosphorylation of EGFR (Tyr845), which in turn inhibits the EGFR/Cyclin D1/CDK4/6 pathway, the EGFR/Akt pathway, and the EGFR/MEK-1/ERK1/2/MMP2 pathway to promote apoptosis and inhibit the proliferation and invasion of GC cells. This evidence concerns the gene AKT1 and gastric cancer.