SFRP1 and cancer: In addition, Feng et al.32 found that exosomal miR-196a-1 regulates SFRP1, binds to the 3' untranslated region of SFRP1 in cancer cells, and promotes GC invasion and liver metastasis by using luciferase reporter assay, bioinformatic analysis, Western blot, and other experimental methods.