STAT3 and non-small cell lung carcinoma: Decitabine (5-aza-2-deoxycytidine) is another DNMTi, which in preclinical studies suppressed NSCLC growth and reduced metastatic potential when combined with acetylsalicylic acid; this effect was mainly achieved via hindering the β-catenin-signal transducer and activator of transcription 3 (STAT3) signaling pathway 6.