Interestingly, further analysis using METABRIC database revealed a significant positive correlation between RNF114 and VEGFR2 in HER2-positive BC patients (n=247), but not in non-HER2-positive subtypes (n=1733) (Figure 4B), indicating that the role of RNF114 involving VEGFR2 in BC may be specific to the HER2-positive subtype. This evidence concerns the gene RNF114 and breast cancer.