SOD1 and diabetes mellitus: Supplementation with exogenous SOD has been reported to enhance the antioxidant defense of the host 31, and a large body of evidence gathered from clinical and animal models suggests that SOD is beneficial in a variety of applications, including reducing fibrosis after radiation therapy; preventing aging, diabetes, tumor formation and hepatitis C-related fibrosis 32 - 35; and reducing the cytotoxic and cardiotoxic effects of anticancer drugs 36.