RHOA and gastric cancer: Rho/Rho-associated protein kinase (ROCK) pathway also plays a key role in gastric cancer cell metastasis and invasion by recruiting IQ domain GTPase activating protein 1 (IQGAP1) 13-16, while IL-6 induces gastric cancer cell invasion by activating the c-Src/RhoA/ROCK signaling pathway 17.