In this study, utilizing the TCGA and GTEx datasets for a comprehensive pan-cancer analysis, we observed that MYBL2 was overexpressed in nearly all tumor types, including ACC, BLCA, CESC, BRCA, COAD, CHOL, DLBC, GBM, ESCA, HNSC, KIRC, KICH, KIRP, LIHC, LGG, LUSC, LUAD, PAAD, OV, PRAD, SARC, READ, STAD, SKCM, THCA, TGCT, UCEC, and UCS (Fig. 5A). This evidence concerns the gene MYBL2 and cancer.