For JUN, the high-risk group was enriched in the "Hedgehog signaling pathway", "selenium amino acid metabolism", "TGF-beta signaling pathway", and "tyrosine metabolism" (Supplementary Figure 2C), whereas the low-risk group was enriched in "allograft rejection" and "systemic lupus erythematosus" (Supplementary Figure 2D). This evidence concerns the gene JUN and systemic lupus erythematosus.