GPX3 and metastatic malignant neoplasm in the lymph nodes: Furthermore, by stratifying GPX3 and JUN into high and low expression groups based on the median, clinical characteristic analysis revealed a significant correlation between the expression levels of GPX3 and pathologic stage, stage T, and stage N. These findings suggest that GPX3 may serve as a potential predictor for the staging and lymph node metastasis of thyroid cancer.