More recently, a significant improvement of the predictive logistic model for AUD with Alcohol-Related Clinical Concerns with ARLD-cirrhosis, was obtained by including retrospective data that qualified the previous AUD condition, i.e., alcohol consumption, age of onset, duration of hazardous alcohol use, and the presence of variant alleles in the PNPLA3 (patatin-like phospholipase-3) and in the HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13) genes (Miscitelli et al., 2018). The gene discussed is HSD17B13; the disease is alcohol dependence.