Thomas et al. [ 25] examined various mechanisms and found that cancer cells use diverse approaches to promote the JAK/STAT pathway; for head and neck SCC, tumor cells express CTLA4,which phosphorylates the STAT3 gene; thus, CTLA4 can positively correlate with STAT3, which is similar to our results.Studies show that increased expression of CTLA4 is associated with several cancers. This evidence concerns the gene STAT3 and neoplasm.