SPP1 and colorectal carcinoma: We assessed the inflammatory, anti-inflammatory, M1, and M2 signatures of different macrophage subsets in CRC-Mix and found that FCN1+ macrophages had the highest inflammatory score and the lowest anti-inflammatory score, with higher M1 scores and lower M2 scores than C1QC+ macrophages and SPP1+ macrophages (Fig. S3E, F).