Isoleucyl-tRNA synthetase 2 (IARS2), a member of the ARS family, is dysregulated in gastric cancer, non-small cell lung cancer, leukemia, and osteosarcoma.14, 15, 16, 17 In this study, we found that up-regulated IARS2 in PDAC tissues was correlated with poor prognosis and unraveled IARS2 functions and mechanisms in PDAC. Here, IARS2 is linked to osteosarcoma.