OMD+ fibroblast could attract pro-tumor CCL2+ macrophage, exhausted CD8+ T cells, and regulatory T cells into the microenvironment through CXCL12 (C-X-C motif chemokine ligand 12)-CXCR4 (C-X-C chemokine receptor 4) interaction.39 This evidence concerns the gene CCL2 and occult macular dystrophy.