This expression pattern of YTHDF1, YTHDF2 and YTHDF3 appeared to be opposite to the p-STAT3 and p-STAT1 counterparts, two earliest activated markers of the inflammatory signaling pathway in ConA-induced hepatitis,25 as well as p-IKBα and p-ERK counterparts, suggesting that YTHDF1, YTHDF2 and YTHDF3 may serve as early warning signals for inflammation (Fig. 1A, B). The gene discussed is YTHDF1; the disease is hepatitis A virus infection.