RPS6KB1 and dementia: Similarly, RPS6KB1 exhibited a robust association with ACD, which remained significant after excluding other ethnic groups [PFDR = 0.004; HR (95% CI): 1.34 (1.18, 1.53)], cases of dementia occurring within the first year of follow-up [PFDR = 0.025; HR (95% CI): 1.31 (1.15, 1.50)], participants aged <60 years [PFDR = 0.031; HR (95% CI): 1.31 (1.14, 1.50)], and it was significantly associated with ACD in the competing risk model [PFDR = 0.014; HR (95% CI): 1.33 (1.16, 1.52)].