EDA2R and early-onset autosomal dominant Alzheimer disease: There was evidence suggesting that Alzheimer’s disease (FinnGen 2023) [β (se): 0.013 (0.049); P = 0.007 (based on IVW)], ACD [β (se): −0.032 (0.012); P = 0.007 (based on IVW)] and VAD [β (se): −0.036 (0.012); P = 0.003 (based on weighted median)] might have a causal link to altered EDA2R abundance.