Albeit being non-significant after FDR correction, of the proteins significantly associated with ACD, based on uncorrected nominal statistical significance (denoted as Puncorrected < 0.05), RPS6KB1 was associated with Alzheimer’s disease [Puncorrected = 0.006; HR (95% CI): 1.29 (1.07, 1.55)]; and NEFL was associated with VAD [Puncorrected = 0.001; HR (95% CI): 1.98 (1.31, 2.99)]. This evidence concerns the gene RPS6KB1 and early-onset autosomal dominant Alzheimer disease.