RPS6KB1 and major depressive disorder: In the fully adjusted models (adjusted for age, sex, ethnicity, education, smoking status, depression, presence of cardiovascular diseases, body mass index, systolic blood pressure, low-density lipoprotein cholesterol), NEFL [PFDR = 0.0008; HR (95% CI): 1.54 (1.29, 1.84)] and RPS6KB1 [PFDR = 0.01; HR (95% CI): 1.33 (1.16, 1.52)] remained significantly associated with ACD (Fig. 1).