Furthermore, there was evidence supporting a causal link between Alzheimer’s disease (Kunkle 2019) and MMP12, demonstrated by MR-Egger, weighted median, and weighted mode methods [β (se): 0.027 (0.012); P = 0.043; β (se): 0.025 (0.012); P = 0.037, and β (se): 0.026 (0.012); P = 0.037, respectively]. The gene discussed is MMP12; the disease is early-onset autosomal dominant Alzheimer disease.