In contrast, baseline atrophy, its progression, tau-PET and Aβ-PET binding were lower in regions that were not structurally connected (baseline atrophy: r = −0.50, P-valuespin = 0.001; atrophy progression: r = −0.36, P-valuespin = 0.001; tau: r = −0.34, P-valuespin = 0.001 and Aβ: r = −0.39, P-valuespin = 0.001). This evidence concerns the gene MAPT and Atrophy.