When comparing Alzheimer's disease with FHAD, a stronger correlation of tau-PET and Aβ-PET with atrophy progression was observed in Alzheimer's disease (tau-PET : rAlzheimer's disease = −0.44 versus rFHAD = −0.05, P-value < 0.0001; Aβ-PET: rAlzheimer's disease = −0.35 versus rFHAD = 0.06, P-value < 0.0001), but no difference was observed with baseline atrophy (tau-PET : rAlzheimer's disease = 0.36 versus rFHAD = 0.38, P-value = 0.73; Aβ-PET: rAlzheimer's disease = 0.23 versus rFHAD = 0.34, P-value = 0.07). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.