In FHAD, using a healthy connectome, we found that the higher the baseline atrophy and its progression, as well as the higher tau-PET and Aβ-PET binding in a region, the higher the baseline atrophy (r = 0.44, P-valuespin = 0.001), atrophy progression (r = 0.36, P-valuespin = 0.02), tau-PET (r = 0.24, P-valuespin = 0.009) and Aβ-PET binding (r = 0.29, P-valuespin = 0.003) in regions that are structurally connected (Supplementary Table 5). Here, MAPT is linked to Atrophy.