MAPT and early-onset autosomal dominant Alzheimer disease: However, both tau-PET and Aβ-PET binding distribution in Alzheimer's disease showed significant spatial overlap with tau-PET (r = 0.91, P-valuespin = 0.001) and Aβ-PET (r = 0.94, P-valuespin = 0.001) binding distribution in FHAD.