BDNF is considered a clinical biomarker for predicting PSD onset, while neuroinflammation and synaptic damage are key pathological changes linked to ischemic stroke (Shan et al., 2021; Zhang et al., 2024; Ramos-Cejudo et al., 2015; Zhang et al., 2024). The gene discussed is BDNF; the disease is ischemic stroke.