NEB and nemaline myopathy: The clinical severity of nemaline myopathy caused by pathogenic NEB variants varies widely, and this variability is closely associated with the amount and size of nebulin protein expressed in muscle tissue, as well as the retention of actin and tropomyosin binding sites [5]. NEB-related myopathy is typically caused by homozygous or compound heterozygous variants; however, in rare cases, dominant variants have also been reported [6].