ANA levels and anti-cardiolipin titers were not statistically significant compared to experimental vs control groups. Anti-b2GPI antibodies was statistically significant between the experimental vs control groups, levels were increased in the experimental group. No association between ANA and MI was found, but there was an association between anti-b2GPI antibodies and MI incidence. This study shows that anti-b2GPI IgG/IgM are independent risk factors for MI in young pre-menopausal women even without the presence of atherosclerotic lesions. Here, CD40LG is linked to Atherosclerotic lesion.