Positive correlation between ANA levels and Gensini scoring (scored severity and extent of coronary stenotic lesions), but no relationship between Rheumatoid factor levels and Gensini scoring. When adjusting for cofounding variable, i.e., age, HTN, DM, hyperlipidemia, smoking, ANA remained independently associated with Gensini scoring in the ACS group. This evidence concerns the gene BTG3 and hypertensive disorder.