Levels of all types of aPL were significantly higher in CAD patients including aβ2GPI in both IgG and IgM, and aCL in both IgG and IgM. LA was also more frequent in CAD group. 13 patients had positive ANA via indirect fluorescence assay, however only one patient did the ELISA test to confirm positivity. This patient had significantly elevated SS-A/Ro-52, and slightly elevated SS-B and Scl-70 antibodies. 23 patients were ANCA positive. Here, CD40LG is linked to coronary artery disorder.