BRAF and adenoma: Furthermore, it is confirmed that WNT/β-catenin signaling activation is concerned with the serrated neoplasia pathway as well as the adenoma-carcinoma sequence in the colorectum [20]. Accordingly, it is probable that the induction of the epithelial-stromal neoplasm as well as the epithelial neoplasms in the colon in this case were related to both BRAF-related and WNT signal pathways.