The Stimulator of Interferon Genes (STING) pathway plays a critical role in the innate immune response to viral infections (18, 19), and it has been reported that hypomethylating agents can induce STING activation mediated by the DNA sensor cyclic GMP-AMP synthase (cGAS) and cyclic GMP-AMP (cGAMP), leading to the production of type 1 interferons (IFN-α and IFN-β) (20, 21). This evidence concerns the gene IFNA1 and viral infectious disease.