CD86 and cancer: As a high CD32, CD64, CD68, CD80, CD86, and IFN-γ–expressing M1 to CD163 and CD204 M2 macrophage polarization often correlates with a better prognosis in patients with cancer (11), we also calculated M1/M2 ratios based on the expression of 188 genes associated with M1 and 159 genes associated with M2 gene signatures (12) and evaluated the values in individual participants at baseline and on treatment.