Silencing REGγ markedly inhibited tumor growth, particularly in the model established with HCT116 cells, which showed unique and higher sensitivity to REGγ depletion (Figure 2D); this was consistent with the results presented in Figure 2, A and B. As expected, we also observed that silencing REGγ markedly attenuated the colony-forming capacity of various KRAS-mutant cancer cell lines (Figure 2E). The gene discussed is KRAS; the disease is cancer.