KRAS and malignant colon neoplasm: First, we performed proteomic analysis using the tandem mass tag (TMT) labeling quantification method to compare a KRAS-mutant colon cancer cell line (HCT8-KRASG13D) with a KRAS–wild type colon cancer cell line (HCT8-KRASWT) (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/JCI185278DS1).