We observed other immune cell phenotypes altered in ARIs, including expansion of CD15+ classical monocytes (cM) (M-0) (OR = 1.30, P = 0.001) in myeloid cells (Figure 4, A–C), and expansion of PAX5lo naive B cells (B-6) (OR = 1.35, P = 0.009) uniquely in the FDR+ACPA+ ARI subgroup, the highest risk group for RA (Figure 5, A–C). This evidence concerns the gene FUT4 and rheumatoid arthritis.