Using coimmunoprecipitation, we demonstrated that knockdown of ZNF638 resulted in significantly decreased levels of TASOR, MPP8, and SETDB1 in GBM cells, suggesting that ZNF638 was critical in maintaining the integrity of the HUSH complex and mediating H3K9me3 repressive histone marks (Figure 5E and Supplemental Figure 3, C and D). Here, MPHOSPH8 is linked to glioblastoma.