Consistent with these findings, our univariate and multivariate COX regression analyses identified Ann Arbor stage (III‐IV), high CXCR5 and LAG‐3 expression rates on CD8+ T cells, and advanced age as independent risk factors for 5‐year PFS and OS in DLBCL patients. The gene discussed is CXCR5; the disease is diffuse large B-cell lymphoma.