The WAVE complex relays signals to the activated Rac, promotes the polymerization of F‐actin, and has roles in vital processes such as cell adhesion and migration.[27, 28, 33, 34] Recent findings have underscored the vital connection of Nckap1l with immune cell function[28, 33, 35, 36, 37, 38] and the development of intrahepatic bile duct networks.[39] Our immunohistochemistry analyses revealed a marked increase in NCKAP1L expression in kidney biopsy samples of individuals with CKD, mainly in renal tubular epithelial cells. This evidence concerns the gene NCKAP1L and chronic kidney disease.