Furthermore, PreS1‐pHLIP NMs treatment recruited significant numbers of F4/80+CD86+ M1‐polarized macrophages and mature DC cells (CD80+CD86+ cells in CD11C+ cells), and significantly decreased F4/80+CD206+ M2‐polarized macrophages, CD11B+GR1+ MDSCs cells and CD4+Foxp3+ Tregs cells into the tumor tissue (Figure S8, Supporting Information). This evidence concerns the gene MRC1 and neoplasm.