Notably, PLXDC1+ TPSCs localized closely with poor prognosis–related LRRC15+ myCAFs,[6]SPP1+ macrophages,[28, 29] and basal‐like malignant cells (Mals),[30, 31, 32] forming a hostile niche around the tumor boundary (Figure 5A–C; Figure S5H,I, Supporting Information). The gene discussed is SPP1; the disease is neoplasm.