PSCs can be activated and promote ECM production by cancer cell supernatants[7] and activated PSCs further promote cancer cell proliferation.[8] PSCs in PDAC are also involved in immunosuppression regulation by secreting CCL3 to recruit regulatory T cells (Tregs) and interleukin (IL)‐6 to promote STAT3‐dependent myeloid‐derived suppressor cell differentiation.[9] Nevertheless, how PSCs interact with neighboring cell types to shape the PDAC TME, is currently unclear. This evidence concerns the gene STAT3 and cancer.