HCs can be stimulated by mechanical sound waves and transmit these sound signals to the cochlear spiral ganglion neurons in the form of electrical signals.[3a] However, HCs are vulnerable to noise, ototoxic drugs, aging, and virus infection, and loss of HCs eventually leads to SNHL.[2b] Lgr5+ progenitors in neonatal mice have limited capacity for HC regeneration through direct transdifferentiation and/or mitotic regeneration,[2, 31] and how to further promote HC regeneration from Lgr5+ progenitors in order to replenish lost HCs is one of the main focuses of research into SNHL. The gene discussed is LGR5; the disease is sensorineural hearing loss disorder.