LGR5 and cancer: Lgr5 is a Wnt‐targeted gene that marks not only somatic stem cells in self‐renewing organs, but also progenitor cells in damaged tissue, such as small intestine,[4] stomach,[5] hair follicle,[6] and liver.[7] In addition, Lgr5 can mark cancer stem cells in intestinal adenomas,[8] gastric cancers,[9] and basal cell carcinomas,[10] which are involved in tumorigenesis.