It was reported that ACE2,[14] 3C‐likeprotease (3CL pro),[15] Papain‐like protease (Plp),[16] and TNF[17] were the key targets in the treatment of COVID‐19, and the binding ability of the key targets to active ingredients in GanCao─GeGen was verified by computer modeling. The gene discussed is ACE2; the disease is COVID-19.