MYC and neoplasm: These data suggested that in BC, SETD8 may involve in regulating tumor growth through MYC, which was also ranked among the top candidates in our previous screening.[3] SETD8 has been previously reported to regulate gene expression by catalyzing H4K20me1.[13] To explore the impact of H4K20me1 on the MYC pathway, we performed a CUT&RUN assay using an anti‐H4K20me1 antibody in SETD8‐knockdown cell lines and observed reduced signals in the promoter and gene body regions of MYC target genes (Figure S2b, Supporting Information).