Aberrant transcriptional and epigenetic landscape is one of the common features of BC.[2b] Our group focused on the key factors essential for bladder tumor growth and discovered a series of novel regulations in previous studies through utilizing CRISPR‐Cas9 screening with a library targeting epigenetic and transcriptional factors.[3, 12] In this report, we discovered that SETD8/MYC axis is critical for BC. This evidence concerns the gene KMT5A and urinary bladder neoplasm.