By co‐transfecting MYC wildtype or K412R mutant with the E3 ligases, which have been reported to mediate MYC degradation in previous studies,[15] we found out that K412R mutant showed increased binding to CHIP (Figure 3j; Figure S3e, Supporting Information), suggesting that in BC, SETD8 inhibits CHIP‐mediated MYC degradation. The gene discussed is KMT5A; the disease is breast cancer.