A recurrent VMP1::RPS6KB1 fusion t(17;17)(q23.1;q23) has been reported in a series of lung adenocarcinoma tumors as well as in esophageal.12,13 For the lung cancer series, this particular fusion does preserve the kinase domain, suggesting a possible role in oncogenesis.12RPS6KB1 was not a target of fusion detection panel in some major commercial NGS pipeline, including Foundation One. This evidence concerns the gene RPS6KB1 and lung cancer.