CXCL5 and head and neck squamous cell carcinoma: TAMs have been identified as the primary source of CCL20 in metastatic primary melanoma.[46] A single‐cell RNA‐sequencing study revealed that infiltrating TAMs in head and neck squamous cell carcinoma secrete higher levels of CCL20 in early‐stage tumors.[47] Considering the crucial role of cytokines in the establishment of the TME between TAMs and ATCSCs, we identified and validated that CCL20 and CXCL5 promoted ATCSCs self‐renewal.