TAMs have been identified as the primary source of CCL20 in metastatic primary melanoma.[46] A single‐cell RNA‐sequencing study revealed that infiltrating TAMs in head and neck squamous cell carcinoma secrete higher levels of CCL20 in early‐stage tumors.[47] Considering the crucial role of cytokines in the establishment of the TME between TAMs and ATCSCs, we identified and validated that CCL20 and CXCL5 promoted ATCSCs self‐renewal. Here, CXCL5 is linked to melanoma.