Moreover, Hiroshima et al., looked at the cell blocks of 41 cases of malignant mesotheliomas and 54 cases of carcinomas from various sites (26 lung carcinomas, 21 ovarian carcinomas, and 7 other carcinomas) and found that HEG-1 was positive in all of the mesothelioma cases and negative in 48 of the 54 cases of carcinomas, with six cases of ovarian origin that were positive (6). The gene discussed is HEG1; the disease is mesothelioma.