However, we did not find significant difference in the proliferation of DG cells (Ki67+) from 5xFAD Ctrl mice and 5xFAD autophagy cKO mice (Figs. 4 and 8), indicating autophagy’s functions in restricting microglia number in AD hippocampus are not likely through increased cell proliferation. Here, MKI67 is linked to Alzheimer disease.