ATG5 and Alzheimer disease: In this study, we found that the deletion of autophagy genes Atg5, Atg14, and Fip200 in microglia significantly increased their number in AD hippocampus at 8-month-old, and the fold of increase was more prominent in male 5xFAD Atg5 cKO microglia (Figs. 3 and 7).