We confirmed that for the antibody previously used in HEK293 cells40, the immunofluorescence signal did not decrease upon siRNA-mediated knockdown of CDIN1 (Supplementary Fig. 1c, d) or HP3-mediated degradation of CDIN1-HF (Supplementary Fig. 1e, f), suggesting that the antibody is nonspecific37. The gene discussed is CDIN1; the disease is hydrops fetalis.