CD8A and cancer: In samples containing both A549 and CD8+ T-cells, the downregulation of TAP1 induced no detectable changes in T-cell killing under control/unstimulated condition (Fig. 3D, 3G and 3J), and only partially increased the cancer cell viability in samples pre-incubated with proinflammatory cytokines (Fig. 3E-F, 3H-I and 3K-L).