As expected from its known function in transporting relatively short 8–16 amino acid long peptides into the ER for HLA loading and subsequent surface membrane transport [42], TAP2 downregulation in lung cancer cells reduces the levels of immunogenic surface HLA-peptide complexes expected to limit the recognition and killing by tumor-antigen specific T-cells under proinflammatory conditions. This evidence concerns the gene TAP2 and neoplasm.