TAP2 and neoplasm: To further assess the role of the IL-4 pathway in TAP2 mediated cancer cell immune evasion and immunotherapy resistance, we studied the role of the IL-4 receptor α (IL-4Rα) blockade in cancer cell elimination using primary autologous tumor/immune-cell co-cultures obtained from disaggregated human NSCLCs expressing low TAP2 levels (Figs. 5S-U and supplementary Figs. S12A-C).