6H-I) and enhanced the levels of HLA-A2-HER2369-377 and HLA-A2-MAGE3271-279 complexes in a concentration-dependent manner (Figs. 6J-K). To further assess the role of HDAC inhibitors in TAP2-mediated adaptive immune evasion, we investigated the cancer cell killing in co-cultures of A549 cells with tumor antigen-specific CD8+ T-cells with or without treatment with SAHA. As shown in Fig. 6L, SAHA enhanced T-cell mediated cytotoxicity of A549 cells. This evidence concerns the gene TAP2 and cancer.