The growth of different tumor cell lines including UACC-62 (melanoma), 786-0 (kidney), NCI-H40 (lung), PC-3 (prostate), NCI-ADR/RES (ovary), and K562 (leukemia) cells was suppressed by purified A. oryzae CCT 3940 L-asparaginase [84]. This evidence concerns the gene ASPG and melanoma.