Also, silencing LDHB did not decrease SLC7A11 expression in KRAS wild-type cancer cells; in fact, an increase in SLC7A11 was observed in HT1080 cells after LDHB silencing (Fig. 3a), but LDHB silencing still sensitized KRAS wild-type cancer cells to GPX4 inhibition (Fig. 2a). Here, KRAS is linked to cancer.