LDHB and non-small cell lung carcinoma: Indeed, the growth of NSCLC A549 xenograft tumors in immunodeficient mice was only slightly delayed by a single treatment with 10 Gy IR, further delayed by LDHB silencing, and most delayed by the combined treatment (Fig. 5g), which also resulted in significantly increased lipid peroxidation levels at the end of the experiment (Supplementary Fig. 5r, s).