Liposomes encapsulating the bisphosphonate clodronate allow specific targeting of macrophages.25 Indeed, the depletion of macrophages via clodronate liposome (CLD-Lp) administration was sufficient to abolish the inhibitory effect of S100a1KD on the tumor growth of LLC cells (Fig. 4g), further confirming that tumor-intrinsic S100A1 requires macrophages to manipulate T-cell immunity and thus tumorigenesis. The gene discussed is S100A1; the disease is neoplasm.