Accumulating evidence suggests that the immune-suppressive TME or immunologically “cold” TME represents a major obstacle to effective immunotherapy.3 This type of TME is characterized by a lack of immune effector cell infiltration, such as CD8+ cytotoxic T lymphocytes, type 1 helper T cells, natural killer cells, mature dendritic cells (DCs), and proinflammatory M1-like tumor-associated macrophages (TAMs). This evidence concerns the gene CD8A and neoplasm.