Randomized controlled trials (RCTs) investigating the effect of dietary weight loss interventions on serum IL‐6 and TNF‐α concentrations in people with obesity lasting at least three months have shown conflicting results, reporting no effect, as well as decreases and increases compared to control.19, 20, 21, 22. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.