In conclusion, this present study demonstrated that obesity is the major risk factor for the development of IVDD, and that lipid transport‐related cytokine, FABP4, plays the critical role in regulating ECM homeostasis in NPCs and angiogenesis via the AGEs‐RAGE/NFκB signalling pathway and VEGF/VEGFR axis, respectively. This evidence concerns the gene FABP4 and obesity disorder.