A variety of mutations have been previously reported in trans‐differentiated melanomas with rhabdomyosarcomatous differentiation, the most common being NF1 (4/4), TP53 (4/4), TERT (2/4), FGFR2/3 (2/4), and CDKN2A (2/4). This evidence concerns the gene CDKN2A and melanoma.