Over the past 20 years, numerous studies have indicated that statin use is associated with T2D, though the underlying mechanism remains unclear.17 Previous studies focused on the effects of statins on pancreatic β-cell function, emphasizing insulin pathways, mitochondrial pathways, and oxidative stress pathways.18 However, they overlooked that statins are inhibitors of hydroxymethylglutaryl coenzyme A reductase, primarily targeting cholesterol synthesis and influencing cholesterol metabolism. This evidence concerns the gene INS and type 2 diabetes mellitus.