MRE11 and cancer: Recent reports advocate (i) Fork degradation by MRE11,[51] (ii) an inhibitory role of MRE11 on fork progression even in BRCA‐proficient cancers[44] and (iii) uncontrolled exonuclease activity of MRE11 expands replication gaps at unprocessed OF, which eventually lead to lethal genomic breaks by the endonuclease activity of MRE11[52] (Figure 8A).