Recently, multiple reports have suggested a role for PARP in DNA replication‐associated events and further, for DNA replication in modulating the sensitivities of cancers to PARPi treatment.[5, 39] Apart from its role in regulating HR, stilbenes including resveratrol and DHS are known to impede DNA replication.[25, 29] DHS inhibits RRM2 (ribonucleotide reductase regulatory subunit M2) mediated synthesis of dNTPs to affect global replication.[29] However, a precise role for DHS in regulating replication machinery and its association with PARPi mediated action is not known. The gene discussed is PARP1; the disease is cancer.