CD8A and plasma cell myeloma: Proper cellular functions rely on the precise regulation of intracellular Ca2+ levels.[40] It has been reported that ApoVs directly contact the membrane of multiple myeloma cells, evoking Ca2+ influx and elevating cytosolic calcium levels.[21] Therefore, we analyzed the levels of calcium after ApoVs interacted with CD8+ T cells in the short and long term, suggesting that ApoVs induced persistent calcium overload of CD8+ T cells with cell membrane fusion (Figure 4D–G), shedding new lights on membrane‐based communication between ApoVs and T cells.