CD8A and autoimmune disease: Nonetheless, when autoreactive responses occur and target the body's own cells, CD8+ T cells can result in autoimmune disorders, graft rejection reactions, and type IV hypersensitivity reactions.[11] Type IV hypersensitivity is involved in the pathogenesis of various diseases, including allergic contact dermatitis, oral lichenoid reactions (OLR), and multiple sclerosis.[12] Given the intricate etiology and varied manifestations of type IV hypersensitivity, the primary treatment focus revolves around symptom management.