CD274 and cancer: For example, tumors are able to increase immunosuppressive cells such as Tregs, MDSCS and “M2-like” macrophage, change cytokine expression and increase immunosuppressive properties (e.g. PD-L1 expression) leading to a Th2 dominant environment all while increasing angiogenesis and tumor growth.102 Moreover, cancer cells can lose MHC and antigen presenting machinery as well as decrease the targeted antigen expression.103,104