Along with p53 antibodies, circulating CTL and CD4+ p53 specific cells have been detected in cancer patients.171–173 While mutp53 is known to promote an immunosuppressive role downregulating MHCI and upregulating immunosuppressive ligands such as PD-L1,174 a cell-mediated innate immune response is present in TNBC patients. This evidence concerns the gene TP53 and cancer.