Li et al. sequenced 4T1.2 and E0771 tumors and designed DNA vaccines encoding a mutant form of ubiquitin (Ubmut) specific for each tumor (Ubmut-4T1.2 DNA and Ubmut-E0771 DNA).119 In an E0771 tumor model, anti-PD-L1 decreased tumor volume while the Ubmut-E0771 DNA vaccine did not significantly reduce tumor volume alone. The gene discussed is CD274; the disease is neoplasm.