For example, tumors are able to increase immunosuppressive cells such as Tregs, MDSCS and “M2-like” macrophage, change cytokine expression and increase immunosuppressive properties (e.g. PD-L1 expression) leading to a Th2 dominant environment all while increasing angiogenesis and tumor growth.102 Moreover, cancer cells can lose MHC and antigen presenting machinery as well as decrease the targeted antigen expression.103,104. The gene discussed is CD274; the disease is neoplasm.