STING1 and neoplasm: In 2 out of 2 fresh tumor samples analyzed, 3% to 5% of gene-marked tumor infiltrating CD45+ cells were detected indicating homing of the engineered macrophages to the TME. Of note, overall Interferon Stimulated Genes (ISGs) expression was increased when first and second surgery tumor tissues were compared thus supporting local delivery of biologically active IFN-α [43].