Although Gonzalez-Ruiz et al. [37] showed that Epi was able to decrease the expression of Murf1 and MAFbx of skeletal muscle (gastrocnemius-soleus) of Long Evans rats, these rats are a model of atrophy by spinal cord injury and not present obesity. Here, FBXO32 is linked to obesity due to melanocortin 4 receptor deficiency.