AKT1 and obesity due to melanocortin 4 receptor deficiency: The mechanism by which this deleterious stimuli induced an increase in the ubiquitin ligase expression is mediated by the decrease in the PI3K/AKT activation, that leads to a decrease in the FOXO phosphorylation, inducing its traslocation to the nucleus, where it acts as transcription factor for the ubiquitin ligases Murf an MAFbx [20], Also, the increased transcription of Murf could be as consequence of the activation of NFκB transcription factor by proinflammatory cytokines, that are increased in the context of obesity [8].